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GlaxoSmithKline Glaxo Wellcome) and current rector of Imperial College. GSK was formed in December 2000 by a merger between Glaxo Wellcome and SmithKline Beecham, both the product of mergers themselves, as recently as 1995 for Glaxo and Wellcome. GSK was actually incorporated in Decmber 1999 as part of the lengthy merger process. As a result of the mergers the company has certain minor businesses which are not strictly within its larger interests. In 2002 pharmaceutical sales accounted for £18 billion of GSK's total sales. Sales are largely based around a small number of successful products, the SSRI Paxil accounted for £2055 million Sources: Pheeds [R=1,P=105],
Total Points: 205.
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Antidepressant and an inability to tolerate these is the most common cause of discontinuing the medication. Sexual dysfunction is a very common side effect. More recent drugs have fewer side effects, but many patients are reporting severe side effects when they try to stop taking some antidepressants, particularly paroxetine. Additionally, certain patients do not respond to antidepressant drugs. Like many psychiatric drugs, antidepressants were discovered by accident. The first antidepressants, imipramine a tricyclic and isoniazid a monoamine oxidase inhibitor (MAOI), were found in the 1950s and the latter was originally intended for the treatment of tuberculosis. These drugs were found to have Sources: Pheeds [R=2,P=52],
Total Points: 152.
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Bupropion HCl Bupropion HCl Bupropion hydrochloride is an amfebutamone anti-depressant unrelated to tricyclics or SSRIs. The patent is owned by GlaxoSmithKline, who sell the compound as Wellbutrin®. It has been shown to aid cessation of cigarette smoking and is sold for this purpose as Zyban. It also promotes weight loss and does not exacerbate acne. Its exact mode of action is unknown. Side effects include sleepnessness. External Links Sources: Pheeds [R=3,P=35],
Total Points: 135.
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Smoking cessation Smoking cessation Smoking cessation is an umbrella term for the effort to stop smoking addictive tobacco products. Effective techniques include: "Cold turkey": stopping by force of will Nicotine replacement therapy (includes transdermal patches and nicotine gum) The antidepressant Zyban (also sold as Wellbutrin) Alternative techniques include: Hypnosis Herbal preparations such as Kava Kava and Chamomile Nutritional nicotine detoxification Acupuncture External Links http://www.quitnet.com Sources: Pheeds [R=4,P=26],
Total Points: 126.
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Zyban Zyban Zyban is the GlaxoSmithKline tradename of a bupropion hydrochloride (amfebutamone, Wellbutrin) sustained release tablet. The drug is sold to help people stop smoking tobacco by reducing the severity of withdrawal symptoms. It can be used in combination with nicotine replacement therapies. Bupropion is a tricyclic aminoketone antidepressant and is marketed as the antidepressant Wellbutrin, the sustained release Sources: Pheeds [R=5,P=21],
Total Points: 121.
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List of antidepressants or selective serotonin reuptake inhibitors 2 MAOIs or monoamine oxidase inhibitors 3 Tricyclics 4 Tetracyclics 5 Others SSRIs or selective serotonin reuptake inhibitors citalopram (Celexa®;, Cipramil®;) escitalopram oxalate (Cipralex®, Lexapro®) fluvoxamine maleate (Luvox®) paroxetine (Paxil®, Seroxat®, Aropax®) fluoxetine (Prozac®) sertraline (Zoloft®, Lustral®) MAOIs or monoamine oxidase inhibitors phenelzine (Nardil®) tranylcypromine (Parnate®) Tricyclics amitriptyline (Elavil®, Endep®) clomipramine (Anafranil®) desipramine (Norpramin®, Pertofrane®) doxepin (Adapin®, Sinequan®) imipramine (Tofranil®) nortryptyline (Pamelor) protriptyline (Vivactil®) trimipramine (Surmontil®) Tetracyclics maprotiline 504 (Ludiomil®) Others bupropion (Wellbutrin®) duloxetine (Cymbalta®) mirtazapine (Remeron®, Zispin®, Avanza®, Norset®, Remergil®) nefazodone (Serzone®) reboxetine (Edronax®, Vestra®) trazodone (Desyrel®) venlafaxine (Effexor®) Sources: Pheeds [R=6,P=17],
Total Points: 117.
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List of psychiatric drugs F Fluoxetine Fluphenazine Flurazepam Fluvoxamine H Halcion Haldol Haloperidol I Imipramine Imovane K Klonopin L Largactil Levoprome Lexapro Libritabs Librium Lithane Lithium Lithizine Lithobid Lithonate Lithotabs Lorazepam Loxapac Loxapine Loxitane Ludiomil Luvox M Maprotiline Mellaril Mesoridazine Methamphetamine Methotrimeprazine Methylphenidate Modecate Minitran N Nardil Navane Nefazodone Norpramine Nortriptyline O Olanzapine Orap Oxazepam P Pamelor Parnate Paroxetine Paxil Pemoline Permitil Perphenazine Pertofrane Phenelzine Phenytoin Pimozide Piportil Pipotiazine Primidone Prolixin Protriptyline Prozac Q Quetiapine R Reboxetine Restoril Rhotrimine Risperidal Risperidone Ritalin S Serax Serentil Seroquel Sertraline Serzone Sinequan Stelazine Strattera Sulpiride Surmontil Symmetrel T Tegretol Temazepam Temposil Thioridazine Thiothixene Thorazine Tofranil Trazodone Trialodine Triazolam Sources: Pheeds [R=7,P=15],
Total Points: 115.
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