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Proton pump inhibitor
of pharmaceuticals with similar action called H2 antagonists. Proton pump inhibitors act by blocking the hydrogen-potassium adenosine triphosphatase enzyme system (the so called proton pump ) of the gastric parietal cell. Hence the enzyme inhibited is the terminal stage in gastric acid production. These drugs are utilized in the treatment of many conditions such as: duodenal and gastric ulcers Zollinger-Ellison syndrome Erosive reflux oesophagitis. Clinically used proton pump inhibitors: Omeprazole (brand names: Prilosec, Losec) Lansoprazole (brand names: Prevacid) Esomeprazole (brand names: Nexium) Pantoprazole (brand names: Protonix) Rabeprazole (brand names: Aciphex)
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